C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/10 (2006.01) A61K 31/435 (2006.01) A61K 31/537 (2006.01) A61P 31/18 (2006.01)
Patent
CA 2554671
This invention relates to piperidine derivatives of formulae (I) with substituents as defined herein useful in the treatment of a variety of disorders, including those in which the modulation of CCR5 receptors is implicated. More particularly, the present invention relates to 1-oxa-3,8- diaza-spiro[4.5]decan-2-one and 1-oxa-3,9-diaza-spiro[5.5]undecan-2-one compounds and related derivatives, to compositions containing and to uses of such derivatives. Disorders that may be treated or prevented by the present derivatives include HIV and genetically related retroviral infections (and the resulting acquired immune deficiency syndrome, AIDS), diseases of the immune system and inflammatory diseases.
L'invention concerne des dérivés de pipéridine de formule (I) présentant des substituants définis dans la description. Ces dérivés sont utiles pour traiter une variété de troubles, notamment les troubles associés à la modulation des récepteurs CCR5. En particulier, l'invention concerne des composés de 1-oxa-3,8-diaza-spiro[4.5]décan-2-one et de 1-oxa-3,9-diaza-spiro[5.5]undécan-2-one et des dérivés associés, des compositions contenant de tels composés et les utilisations de tels dérivés. Des troubles peuvent être traités ou prévenus par les dérivés de l'invention, notamment des troubles comme le VIH et des infections rétrovirales génétiquement associées (et le syndrome d'immunodéficience acquise résultant, SIDA), des maladies du système immunitaire et des maladies inflammatoires.
Gabriel Stephen Deems
Rotstein David Mark
F.hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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