C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 2/00 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) C07K 14/00 (2006.01) C07K 14/52 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2365970
Synthetic peptide analogs of chemokines are designed to include the N- and C- terminal portions of the corresponding naturally occurring chemokine. In particular, synthetic peptide analogs of stromal cell-derived factor-1 (SDF-1) are effective in inhibiting HIV-1 entry and infection via the CXC chemokine receptor 4 (CXCR4). Each peptide comprises a peptide segment analog of the SDF- 1 N-terminal region joined to a peptide segment analog of the SDF-1 C-terminal region. The peptides are useful for HIV treatment and prophylaxis.
L'invention concerne des analogues peptidiques synthétiques de chimiokines conçus pour inclure les parties N-terminale et C-terminale des chimiokines naturelles correspondantes. En particulier, les analogues peptidiques synthétiques du facteur 1 dérivé des cellules de stroma (SDF-1) sont efficaces pour inhiber la pénétration et l'infection par le VIH-1 via le récepteur 4 de chimiokine CXC (CXCR4). Chaque peptide comprend un analogue de segment peptidique de la région N-terminale du facteur SDF-1 rattaché à un analogue de segment peptidique de la région C-terminale du facteur SDF-1. Les peptides considérés sont utiles pour le traitement et la prophylaxie du VIH.
Huang Ziwei
Luo Jiansong
Luo Zhaowen
Zhou Naiming
Gowling Lafleur Henderson Llp
Thomas Jefferson University
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