Chemokine inhibitor

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 19/00 (2006.01) A61K 38/16 (2006.01) C07K 14/065 (2006.01) C07K 14/07 (2006.01) C07K 14/52 (2006.01) C07K 16/00 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2232706

A protein designated p35 binds to a number of the chemotaxis-stimulating cytokines known as chemokines. p35 may be used to treat conditions that are mediated by chemokines, such as inflammation. p35 is a secreted protein that can be purified from the culture supernatant of cells infected with certain viruses, or produced using recombinant DNA techniques. Isolated DNA sequences encoding p35 are provided, along with expression vectors comprising the p35 DNA, and purified p35 protein.

L'invention concerne une protéine désignée sous l'appellation p35 qui se lie à un certain nombre de cytokines stimulant la chimiotaxie, connues sous le nom de chemokines. La protéine p35 peut être utilisée pour traiter des états provoqués par les chemokines, par exemple des inflammations. La protéine p35 est une protéine sécrétée, pouvant être purifiée à partir de surnageants de culture de cellules infectées par certains virus, ou pouvant être produite par des techniques de recombinaison de l'ADN. On décrit les séquences d'ADN isolés codant p35, ainsi que les vecteurs d'expression contenant l'ADN de p35, et la protéine p35 purifiée.

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