C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) C07K 14/52 (2006.01) C07K 14/54 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) C12N 15/24 (2006.01) G01N 33/554 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2202889
The invention relates to novel chemokine-like proteins that include two or more newly discovered active domains from different chemokines. Active domains are regions of several contiguous amino acids that are necessary for chemokines' ability to suppress the proliferation of actively dividing myeloid cells, e.g., myeloid progenitor cells, myeloid stem cells, and leukemic cells. The new chemokine-like proteins provide higher myelosuppressive activity than naturally occurring, wild-type chemokines.
L'invention concerne des protéines nouvelles, analogues à des chimiokines, qui comportent au moins deux domaines actifs, récemment découverts, de différentes chimiokines. Les domaines actifs sont des régions de plusieurs acides aminés contigus qui sont nécessaires à la capacité qu'ont les chimiokines d'arrêter la prolifération de cellules myéloïdes qui se divisent activement, par exemple les cellules progénitrices myéloïdes, les cellules souches myéloïdes et les cellules leucémiques. Les nouvelles protéines analogues à des chimiokines donnent une plus grande activité myélodépressive que les chimiokines de type sauvage qui se rencontrent naturellement.
Daly Thomas J.
Larosa Gregory J.
Repligen Corporation
Smart & Biggar
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