Chemokine receptor antagonist and cyclosporin in combined...

A - Human Necessities – 61 – K

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Details

A61K 38/19 (2006.01) A61K 38/00 (2006.01) A61K 38/13 (2006.01) A61K 45/00 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2344370

The use of a chemokine receptor antagonist together with a cyclosporin to produce a pharmaceutical composition for treating or preventing rejection of transplanted organs, tissues or cells is herein disclosed. Said pharmaceutical compositions for the simultaneous, separate or sequential use of its active ingredients for the above specified therapy are also disclosed and claimed. In particular, the use of Met-RANTES together with cyclosporin A to produce a pharmaceutical composition for the treatment of renal allograft transplant rejection is experimentally shown.

L'invention concerne un antagoniste du récepteur de la chimiokine utilisé avec une cyclosporine pour produire une composition pharmaceutique destinée à traiter ou à prévenir le rejet d'organes, de tissus ou de cellules greffés. L'invention traite également desdites compositions pharmaceutiques conçues pour une utilisation de façon simultanée, séparée ou séquentielle de leurs principes actifs pour la thérapie susmentionnée. En particulier, l'utilisation de Met-Rantes avec de la cyclosporine A pour produire une composition pharmaceutique destinée au traitement du rejet d'une allogreffe rénale est illustrée expérimentalement.

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