Chemokine receptor antagonists

Details Chemokine receptor antagonists Chemokine receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 401/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 451/14 (2006.01) C07D 471/08 (2006.01)

Patent

CA 2261633

Compounds represented by general formula (I), pharmaceutically acceptable anion-exchange products thereof, or hydrates of both, wherein R1 and R2 are the same or different and each represents hydrogen, halogeno, lower alkyl, etc.; X represents oxygen, sulfur or CH; Y represents CH or nitrogen; and A represents 1-substituted-4-piperidinyl, etc. Because of having chemokine receptor antagonism, these compounds are useful as remedies for various diseases related to chemokine, such as acute inflammatory diseases, chronic inflammatory diseases, human acquired immunological deficiency syndrome, cancer, ischemic reflow disorders and/or arteriosclerosis.

Composés représentés par la formule générale (I), dans laquelle R?1¿ et R?2¿ sont identiques ou différents, chacun représentant hydrogène, halogène, alkyle inférieur etc.; X représente l'oxygène, le soufre ou CH; Y représente CH ou l'azote; et A représente 4-pipéridinyle substitué en 1, etc., produits d'échange anionique pharmaceutiquement acceptables de cette formule, ou formes hydrates de ces composés ou produits. En raison de leur propriété antagoniste des récepteurs de chemokine, ces composants sont utiles comme remèdes pour diverses maladies liées aux chemokines, telles les maladies inflammatoires aiguës et chroniques, le syndrome immunodéficitaire acquis humain, les cancers, les troubles ischémiques et/ou l'artériosclérose.

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