C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/44 (2006.01) A61K 31/4015 (2006.01) A61P 31/18 (2006.01) C12N 1/14 (2006.01) C12P 17/10 (2006.01)
Patent
CA 2404312
Novel tetramic acid-type compounds isolated from a CCR-5 active complex produced by fermentation under controlled conditions of a biologically pure culture of the microorganism, Chaetomium globosum Kunze SCH 1705, ATCC 74489., pharmaceutical compositions containing the compounds and the use of the CCR-5 antagonist compounds and compositions to treat HIV-1 infections in humans are disclosed.
L'invention concerne de nouveaux composés tétramiques de type acide isolés d'un complexe CCR-5 actif obtenu par fermentation, dans des conditions contrôlées, d'une culture biologiquement pure du micro-organisme Chaetomium globosum Kunze SCH 1705, ATCC 74489. L'invention concerne en outre des compositions pharmaceutiques contenant lesdits composés, et l'utilisation des composés et compositions antagonistes de CCR-5 pour traiter des infections à VIH-1 chez l'humain.
Chu Min
Mierzwa Ronald A.
Patel Mahesh G.
Terracciano Joseph
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Schering Corporation
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