Chemokine receptor binding heterocyclic compounds

Details Chemokine receptor binding heterocyclic compounds Chemokine receptor binding heterocyclic compounds

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/44 (2006.01) A61P 31/18 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2389545

The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV- or FIV- infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.

L'invention concerne des composés antiviraux, des compositions pharmaceutiques et leurs utilisations. Elle concerne plus spécifiquement des dérivés de polyamines monocycliques qui possèdent une activité, dans des tests standards, contre des cellules infectées par VIH ou par FIV, aussi bien que d'autres activités biologiques se rapportant au pouvoir de liaison de ligands à des récepteurs de chemokine qui assurent une médiation dans un certain nombre de processus de développement embryonnaire de mammifères.

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