Chemokine receptors 88-2b [ckr-3] and 88c and their antibodies

Details Chemokine receptors 88-2b [ckr-3] and 88c and their antibodies Chemokine receptors 88-2b [ckr-3] and 88c and their antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) C07K 14/715 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 5/18 (2006.01)

Patent

CA 2213331

The present invention provides polynucleotides that encode the chemokine receptors 88-2B or 88C and materials and methods for the recombinant production of these two chemokine receptors. Also provided are assays utilizing the polynucleotides which facilitate the identification of ligands and modulators of the chemokine receptors. Receptors fragments, ligands, modulators, and antibodies are useful in the detection and treatment of disease states associated with the chemokine receptors such as atherosclerosis, rheumatoid arthritis, tumor growth suppression, asthma, viral infection, AIDS, and other inflammatory conditions.

La présente invention concerne des polynucléotides encodant les récepteurs 88-2B ou 88C de la chimiokine et des matériaux et méthodes pour la production recombinante de ces deux récepteurs de la chimiokine. L'invention concerne également des épreuves utilisant des polynucléotides qui facilitent l'identification de ligands et de modulateurs des récepteurs de la chimiokine. Les fragments, ligands, modulateurs et anticorps des récepteurs sont utiles pour la dépistage et le traitement d'états pathologiques associés aux récepteurs de la chimiokine, telles que l'athérosclérose, la polyarthrite rhumatoïde, la suppression de la croissance tumorale, l'asthme, les infections virales, le sida et d'autres maladies inflammatoires.

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