Chemokines as adjuvants of immune response

A - Human Necessities – 61 – K

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A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2434320

Dendritic cells play a critical role in antigen-specific immune responses. Materials and methods are provided for treating disease states, including cancer and autoimmune disease, by facilitating or inhibiting the migration or activation of antigen-presenting dendritic cells. In particular, chemokines are used to initiate, amplify or modulate an immune response. In one embodiment, chemokines are used to attract dentritic cells to the site of antigen delivery. An increase number of dendritic at the site of antigen delivery means more antigen uptake and a modified immune response.

Selon la présente invention, les cellules dendritiques jouent un rôle déterminant dans les réponses immunitaires spécifiques aux antigènes. Cette invention concerne des substances et des méthodes destinées à traiter des états pathologiques, tels que le cancer et les maladies auto-immunes, en favorisant ou en inhibant la migration ou l'activation de cellules dendritiques de présentation antigénique. Plus particulièrement, on utilise des chimiokines pour induire, amplifier ou moduler une réponse immunitaire. Dans un mode de réalisation, ces chimiokines sont utilisées pour attirer des cellules dendritiques vers le site d'administration d'antigènes. Un nombre accru de cellules dendritiques au niveau du site d'administration d'antigènes indique une augmentation de l'absorption antigénique et une modification de la réponse immunitaire.

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