Chemokines as adjuvants of immune response

A - Human Necessities – 61 – K

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A61K 38/16 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 39/39 (2006.01)

Patent

CA 2460321

Dendritic cells play a critical role in antigen-specific immune responses. Materials and methods are provided for treating disease states, including cancer, infectious diseases, autoimmune diseases, transplantation, and allergy by facilitating or inhibiting the migration or activation of a specific subset of antigen-presenting dendritic cells known as plasmacytoid dendritic cells (pDC). In particular, methods for treating disease states are provided comprising administration of chemokine receptor agonists and antagonists, alone or in combination with a disease-associated antigen, with or without an activating agent.

Les cellules dendritiques jouent un rôle important dans les réponses immunitaires antigène-spécifiques. La présente invention concerne des substances et des procédés permettant de traiter les états pathologiques comprenant le cancer, les maladies infectieuses, les maladies auto-immunes, les états pathologiques liés à la transplantation, et l'allergie, en facilitant ou en inhibant la migration ou l'activation d'un sous-ensemble spécifique de cellules dendritiques de présentation de l'antigène connues sous le nom de cellules dendritiques plasmacytoïdes (pDC). En particulier, l'invention a pour objet des procédés permettant le traitement d'états pathologiques, comprenant l'administration d'agonistes et d'antagonistes du récepteur de la chimiokine, seuls ou en combinaison avec une antigène associé à la maladie, avec ou sans agent d'activation.

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