Chemokines mutants having improved oral bioavailability

Details Chemokines mutants having improved oral bioavailability Chemokines mutants having improved oral bioavailability

A - Human Necessities

61

K

A61K 38/19 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 37/00 (2006.01) C07K 14/52 (2006.01)

Patent

CA 2480692

The oral efficacy of C-C- chemokines containing a dibasic site in the 40's conserved cationic sequence, such as RANTES and MIP-1beta, is improved by substituting at least one of the residues in the dibasic site in a non- conservative manner.

L'efficacité orale de chimiokines C-C contenant un site dibasique dans la 40 ème séquence cationique conservée, comme RANTES et MIP-1bêta, est améliorée par substitution d'au moins un des résidus dans le site dibasique de manière non restrictive.

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