C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
167/114, 195/46,
C12P 21/00 (2006.01) A61K 35/14 (2006.01)
Patent
CA 1188245
-1- Abstract: New chemokinesins and chemotaxins of leukocytes and inflamed tissue are described having the following properties: a) biological activities in vivo and in vitro: selective reversible influence on the motility of leuko- cytes (chemokinesis) or selective chemical attraction of leukocytes (chemotaxis) in vitro; b) physico-chemical properties: soluble in aqueous media including in 15% ethanol at a pH value of at least 4.0 to 10; insoluble in ammonium sulfate solution at 90% saturation (3.6 mol/1); electrophoretic migration in acrylamide matrices at a pH of 7.40 is anodic; adsorb reversibly in structure and biological activity on anion and cation exchangers, calcium phosphate gel and hydroxyapatite and can be subjected in native form to volume partition chromatography, character- ized by homogenizing leukocytes or inflamed tissue or culturing leukocytes and isolating the resultant chemo- kinesins and chemotaxins from the homogenates or the supernatant culture solution. The compounds selectively influence the motility of leukocytes or selectively attract leukocytes.
398628
Kirby Eades Gale Baker
Planck (max) Gesellschaft Zur Forderung Der Wissenschaften E.v.
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