Chemoprotective bacterial strains

Details Chemoprotective bacterial strains Chemoprotective bacterial strains

A - Human Necessities

61

K

A61K 38/44 (2006.01) A23C 9/123 (2006.01) A61K 38/45 (2006.01)

Patent

CA 2311613

This invention provides compositions and methods for supplementing the detoxification systems of gastrointestinal cells to protect the body from ingested procarcinogens and other toxic substances. The compositions comprise probiotic microorganisms which have been genetically modified to express mammalian enzymes involved in detoxification of procarcinogens. The invention is practiced by feeding or otherwise administering the engineered probiotic organisms to an animal or human. The organisms colonize or otherwise become associated with the GI tract of the individual, whereupon they grow and multiply, continuing to produce the detoxifying enzymes.

La présente invention concerne des compositions et des procédés utilisés pour compléter l'action des systèmes de détoxication des cellules gastro-intestinales, de façon à protéger l'organisme des procancérogène ingérés et d'autres substances toxiques. Ces compositions renferment des micro-organismes probiotiques génétiquement modifiés pour exprimer les enzymes mammifères impliquées dans la détoxication des procancérogènes. Le procédé de cette invention consiste à administrer les organismes probiotiques élaborés à un animal ou à un humain. Ces organismes s'associent à la voie gastro-intestinale du sujet ou la colonisent, puis se développent et se multiplient, tout en continuant à produire des enzymes de détoxication.

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