C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
167/114, 195/46,
C12P 21/00 (2006.01) A61K 35/14 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1188243
-1- Abstract: New chemorecruitins of leukocytes and inflamed tissue are described having the following properties: a) biological activities in vivo and in vitro: specific induction of selective positive leukocytosis and/or leftward shift reactions by recruitment of mature and juvenile leukocytes from the bone marrow into the blood in vivo and in vitro; positive mobilization of mature and juvenile leukocytes directly from the bone marrow in vitro (also in blood- free systems, for instance cell culture and salt solu- tions); substantial freedom of other biological effects; b) physico-chemical properties: no protein quaternary structure in the form of physically bound peptide subunits: each of the native proteins consists of only one peptide unit; electrophoretic migration in acrylamide matrices at a pH of 7.40 is anodic; soluble in aqueous media including in 15% ethanol at a pH value of at least 4.0 to 10; constant temperature coefficient of solubility in ammonium sulfate solutions between -10°C and +50°C; contain, amongst others, the amino acids tyrosine, phenylalanine, alanine, glycine, lysine, valine, glutamic acid, arginine, leucine; adsorb reversibly in structure and biological activity on anion and cation exchangers, calcium phosphate gel and hydroxyapatite and can be subjected in native form to volume partition chromatography. The compounds selec- tively induce a leukocytosis reaction and/or a leftward shift reaction in vivo.
398605
Kirby Eades Gale Baker
Planck (max) Gesellschaft Zur Forderung Der Wissenschaften E.v.
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