Chemosensitizing with liposomes containing oligonucleotides

Details Chemosensitizing with liposomes containing oligonucleotides Chemosensitizing with liposomes containing oligonucleotides

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 31/7088 (2006.01) A61K 31/7125 (2006.01) A61K 41/00 (2006.01) A61K 45/06 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2476437

The invention relates to the use of oliognucleotide containing cationic liposomal formulations to enhance the efficacy of chemotherapy and/or radiotherapy, particularly as a means to chemosensitize cancer are tumor tissues to the efficiencies of chemotherapy. This is particularly advantageous in the context of treatment of ras expressing tumors such as breast, lung, pancreatic and prostate cancer.

L'invention concerne l'utilisation de formulations liposomales cationiques contenant des oligonucl~otides en vue d'am~liorer l'efficacit~ de la chimioth~rapie et/ou de la radioth~rapie, notamment comme moyen pour chimiosensibiliser un cancer et des tissus tumoraux ~ l'action de la chimioth~rapie. Ces formulations sont particuli­rement avantageuses dans le contexte du traitement de tumeurs exprimant le g­ne ras telles que le cancer du sein, des poumons, du pancr~as et de la prostate.

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