C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 51/08 (2006.01) C07K 7/02 (2006.01)
Patent
CA 2289314
Radiopharmaceuticals comprising molecules that target to N-formyl-methionyl- leucyl-phenylalanine (fMLF) receptor on leukocytes in order to target sites of inflammation for diagnostic imaging are described. The targeting molecules are attached to capping groups that make the entire molecule either antagonists or weak agonists of fMLF receptor and therefore do not elicit a chemotactic response resulting in neutropenia. The preferred targeting molecule is ReO-Gly-lys(Dimethylgly-t- Butylgly-cys-gly) -glu-trp-phe-leu-nle-NHCOcyclopropyl. The invention also relates to the use of combinatorial chemistry to obtain preferred molecules that target sites of inflammation for diagnostic imaging.
Lawrence Betty Chee-Ion
Pollak Alfred
Pollock Catherine Michelle
Ribic Christine Maria
Roe David
Bracco International B.v.
Dimock Stratton Llp
Resolution Pharmaceuticals Inc.
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