Chemotherapeutant screening method

Details Chemotherapeutant screening method Chemotherapeutant screening method

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) A61P 43/00 (2006.01) C12N 15/09 (2006.01) C12Q 1/02 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) A61K 31/513 (2006.01)

Patent

CA 2395524

Disclosed is a method for determining whether a test compound is effective for a chemotherapy.The inventive method comprises the following steps: a) a DNA sequence is provided, whereby said sequence comprises site AP-1 represented in figure 5A as a constituent of a promoter, preferably promoter CD95L, which is functionally linked to a reporter gene or the CD95L gene, b) the DNA sequence a) is brought into contact with the test compound in a cellular assay, and c) activation of the promoter is determined, said activation indicating that the test compound is effective for a chemotherapy.

Procédé qui permet de déterminer si un composé à l'essai est efficace pour une chimiothérapie. Ledit procédé consiste (a) à disposer d'une séquence d'ADN qui comprend le site AP-1 représenté à la figure 5A en tant que partie d'un promoteur, de préférence du promoteur CD95L, lié de manière fonctionnelle avec un gène reporter ou avec le gène CD95L, (b) à mettre en contact la séquence d'ADN de l'étape (a) avec le composé à l'essai dans un milieu cellulaire et (c) à déterminer l'activation du promoteur, la présence d'une activation indiquant que le composé à l'essai est efficace pour une chimiothérapie.

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