Chemotherapeutic agent

Details Chemotherapeutic agent Chemotherapeutic agent

C - Chemistry, Metallurgy

07

D

260/356

C07D 311/60 (2006.01) C07C 49/835 (2006.01) C07C 49/84 (2006.01)

Patent

CA 1193273

ABSTRACT Mono-, di- and tri-substituted flavan derivatives of formula (II), (II) Image and pharmaceutically acceptable salts, thereof, wherein RA represents hydrogen or up to two substituents selected from the class consisting of halogen, nitro, cyano, tri- fluoromethyl, (C1-C4)alkylamino and (C1-C4) alkyl, and RB represents hydrogen or up to two substituents selected from the class consisting of halogen, nitro, cyano, tri- fluoromethyl, (C1-C4)alkylamino, amino, (C1-C4)alkyl, (C1-C4)alkoxy except 4'-(C1-C4)alkoxy, hydroxyethoxy and hydroxy except 4'-hydroxy, provided that, when RB represents two hydrogen atoms, RA does not represent two hydrogen atoms and one of the substituents represented by RA is other than (C1-C4)alkyl and also provided that RA and RB represent at least one hydrogen atom, are active against viruses, especially rhinoviruses; methods for producing the derivatives are described, as are pharmaceutical formulations and methods for administer- ing the derivatives to cure or prevent rhinoviral infections.

323442

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