Chemotherapeutic composition and method

Details Chemotherapeutic composition and method Chemotherapeutic composition and method

A - Human Necessities

61

K

A61K 45/06 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2353905

The present invention relates to a composition and method comprising Mycobacterium phlei (M. phlei)-DNA (M-DNA), M-DNA preserved and complexed on M. phlei cell wall (MCC), a chemotherapeutic agent and a pharmaceutically acceptable carrier, wherein the M-DNA and the MCC induce cell cycle arrest in proliferating cancer cells, inhibit proliferation of cancer cells, induce apoptosis in cancer cells and potentiate the antineoplastic effect of the chemotherapeutic agent on cancer cells.

Cette invention concerne une méthode de chimiothérapie faisant intervenir une composition qui contient de l'ADN de Mycobacterium phlei (ADN-M. phlei) (ADN-M). L'ADN-M, conservé et complexé sur la paroi cellulaire des M. phlei (MCC) est un agent de chimiothérapie acceptable sur le plan pharmaceutique. L'ADN-M et le MCC provoquent l'arrêt du cycle cellulaire des cellules cancéreuses en prolifération, limitent la prolifération des cellules cancéreuses, provoquent l'apoptose des cellules cancéreuses et améliorent l'action antitumorale de l'agent de chimiothérapie sur les cellules cancéreuses.

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