Chemotherapeutic formulations of zosuquidar trihydrochloride...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 31/5415 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2630087

The present invention relates to a method of treating patients with leukemias, solid tumors, and other malignancies using chemotherapeutic agents in combination with zosuquidar that has been solubilized by a modified cyclodextrin, such as sulfobutylcyclodextrin or hydroxypropyl cyclodextrin. The invention is also directed to pharmaceutical formulations comprising zosuquidar in combination with a modified cyclodextrin.

La présente invention concerne un procédé de traitement de patients souffrant de leucémies, de tumeurs solides et autres malignités à l'aide d'agents chimiothérapeutiques en association avec du zosuquidar qui a été solubilisé par une cyclodextrine modifiée, telle qu'une sulfobutylcyclodextrine ou une hydroxypropyle cyclodextrine. L'invention concerne également des formulations pharmaceutiques comportant du zosuquidar en association avec une cyclodextrine modifiée.

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