Chemotherapeutic microemulsion compositions of paclitaxel...

A - Human Necessities – 61 – K

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A61K 31/337 (2006.01) A61K 9/107 (2006.01) A61K 9/48 (2006.01) A61K 31/00 (2006.01) A61K 31/122 (2006.01) A61K 31/352 (2006.01) A61K 31/365 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/444 (2006.01) A61K 31/50 (2006.01) A61K 31/52 (2006.01) A61K 47/38 (2006.01) A61K 47/44 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2434641

Pharmaceutical compositions suitable for oral administration comprising paclitaxel, a solvent, a surfactant, a substituted cellulosic polymer, and optionally but preferably a P-glycoprotein inhibitor. The composition may further comprise a diglyceride or mixture of diglyceride and monoglyceride. The composition generates a supersaturated paclitaxel microemulsion upon contact with water resulting in improved oral bioavailability of paclitaxel.

L'invention concerne des préparations pharmaceutiques adaptées pour l'administration orale contenant du paclitaxel, un solvant, un surfactant, un polymère cellulosique substitué et éventuellement mais de préférence un inhibiteur P-glycoprotéine. Cette préparation peut également contenir un diglycéride ou un mélange de diglycéride et de monoglycéride. La préparation produit une microémulsion de paclitaxel sursaturée lors du contact avec l'eau, ce qui procure une meilleure biodisponibilité de paclitaxel.

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