Chenodeoxycholic acid

Details Chenodeoxycholic acid Chenodeoxycholic acid

C - Chemistry, Metallurgy

07

J

167/109, 260/62

C07J 9/00 (2006.01)

Patent

CA 1041479

ABSTRACT A method of isolating chenodeoxycholic acid from hog bile is provided, which comprises the steps of treating the hog bile under saponifying conditions to obtain a mixture of bile acids; isolating the bile acids from the remaining constituents of the saponified bile; esterifying the bile acids to obtain a mixture of bile acid esters; isolating from the mixture of bile acid esters the hyodeoxycholic acid ester as its adduct with a compound selected from the group consisting of benzene and toluene; treating the remaining bile acid esters under acetylating conditions isolating the hyocholic acid ester triacetate; isolating the chenodeoxycholic acid ester diacetate; treating the chenodeoxy- cholic acid ester diacetate under saponifying conditions; isolating the chenodeoxycholic acid thus obtained; and, purifying the chenodeoxycholic acid. The method described yields chenodeoxycholic acid of exceedingly high purity, which may be used in the treatment of gallstones by their dissolution in vivo.

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