Chicken interleukin-15 and uses thereof

Details Chicken interleukin-15 and uses thereof Chicken interleukin-15 and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/24 (2006.01) A61K 38/20 (2006.01) A61K 39/12 (2006.01) A61K 39/17 (2006.01) A61K 39/255 (2006.01) A61K 39/39 (2006.01) C07K 14/54 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2231603

The present invention provides isolated and purified DNA encoding avian interleukin-15 (IL-15), as well as cloning and expression vectors comprising IL-15 DNA and cells transformed with IL-15-encoding vectors. The invention also provides isolated and purified avian IL-15 polypeptide which has the ability to stimulate mitogen-activated avian T cells. The invention also provides a method for enhancing an immune response in fowl to an immunogen by administering the immunogen before, after, or simultaneously with avian IL-15. Finally, the invention provides a vaccine for inducing immune responses in fowl to an immunogen comprising the immunogen and an effective amount of avian IL-15.

La présente invention concerne de l'ADN isolé et purifié codant l'interleukine-15 (IL-15) d'origine aviaire, ainsi que des vecteurs de clonage et d'expression comprenant de l'ADN à IL-15 et des cellules transformées au moyen de vecteurs codant l'IL-15. L'invention concerne également un polypeptide isolé et purifié de l'IL-15 d'origine aviaire, lequel polypeptide a la possibilité de simuler des lymphocytes T d'origine aviaire rendus actifs par un mitogène. L'invention concerne aussi un procédé permettant de renforcer chez la volaille une réponse immunitaire à un immunogène par administration de l'immunogène avant, après, ou en même temps que l'IL-15. L'invention concerne enfin un vaccin permettant d'induire chez la volaille des réponses immunitaires à un immunogène, ce vaccin comprenant ledit immunogène et une quantité suffisante d'IL-15 d'origine aviaire.

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