Chimaeric interleukin 5-receptor/immunoglobulin polypeptides

C - Chemistry – Metallurgy – 12 – N

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C12N 15/62 (2006.01) A61K 38/20 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01) C12N 15/24 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2078384

RAN4105/144 Abstract The present invention is directed to a DNA sequence comprising two partial DNA sequences, one partial sequence coding for a fragment of the .alpha.- and/or the .beta.-chain of the human interleukin-5 receptor which fragment or combination of fragments binds human interleukin-5 and the other partial sequence coding for the constant domains of a heavy- or a light chain of a human immunoglobulin such as IgG, IgA, IgM or IgE or a part thereof, a vector comprising such a DNA sequence, a pro- or eukaroytic host cell transformed with such a vector, a recombinant protein coded for by such a DNA sequence, a process for the preparation of such recombinant protein and a pharmaceutical composition containing such a recombinant protein.

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