Chimera botulinum toxin type e

Details Chimera botulinum toxin type e Chimera botulinum toxin type e

C - Chemistry, Metallurgy

07

K

C07K 14/33 (2006.01) C12N 15/31 (2006.01)

Patent

CA 2552947

The present invention relates to a toxin comprising a modified light chain of a botulinum toxin type E, wherein the modified light chain comprises amino acid sequence PFVNKQFN (SEQ ID NO: 144) at the N-terminus, and amino acid sequence xExxxLL (SEQ ID NO: 112) at the C-terminus, wherein x is any amino acid.

L'invention concerne une toxine qui comprend une chaîne légère modifiée de toxine botulinum de type E, ladite chaîne comportant une séquence d'acides aminés PFVNKQFN (SEQ ID NO: 144) en terminaison N, et une séquence d'acides aminés xExxxLL (SEQ ID NO: 112) en terminaison C, x étant un acide aminé quelconque.

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