Chimera (double) decoy

Details Chimera (double) decoy Chimera (double) decoy

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61P 1/04 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 17/02 (2006.01) A61P 17/04 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2583576

It is intended to provide a drug for preventing, ameliorating or treating vascular restenosis, ischemic diseases, allergic diseases, inflammatory diseases, autoimmune diseases, cancer metastasis or infiltration (cancerous metastasis/infiltration) or cachexia based on the inhibition of a plural number of transcriptional regulators. Namely, a chimeric (double) decoy (a decoy molecule) having a plural number of transcriptional regulator-binding sequences per molecule. Thus, it can inhibit a plural number of transcriptional regulator-inhibiting activities by a single molecule. For example, stenosis in an inosculation site of an artificial vessel is resulted from thickening in the vascular endosporium mainly caused by activated cell proliferation due to an inflammatory reaction in the inosculation site. By simultaneously inhibiting two transcriptional regulators participating in the inflammation and the cell proliferation with the use of the above-described chimeric decoy, therefore, the thickening in the vascular wall can be inhibited.

L~invention concerne un médicament pour prévenir, améliorer ou traiter la resténose vasculaire, les maladies ischémiques, les maladies allergiques, les maladies inflammatoires, les maladies auto-immunes, les métastases cancéreuses ou l~infiltration cancéreuse ou la cachexie reposant sur l~inhibition d~un nombre pluriel de régulateurs de transcription. Spécifiquement l'invention concerne un leurre chimère (double) (molécule leurre) possédant un nombre pluriel de séquences de liaison de régulateurs de transcription par molécule. Ainsi, elle permet d~inhiber un nombre pluriel d~activités inhibitrices de régulateurs de transcription par une simple molécule. Par exemple, la sténose sur un site d~inoculation d~un vaisseau artificiel résulte de l~épaississement de l~endospore vasculaire principalement causé par l~activation de la prolifération cellulaire due à une réaction inflammatoire dans le site d~inoculation. L~inhibition simultanée de deux régulateurs de transcription participant à l~inflammation et à la prolifération cellulaire en utilisant le leurre chimère décrit ci-dessus permet par conséquent d~inhiber tout épaississement dans la paroi vasculaire.

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