C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/861 (2006.01) A61K 48/00 (2006.01) C12N 7/01 (2006.01) C12N 7/02 (2006.01)
Patent
CA 2567094
The present invention relates to oncolytic adenoviruses having therapeutic applications. Recombinant chimeric adenoviruses, and methods to produce them are provided. The chimeric adenoviruses of the invention comprise nucleic acid sequences derived from adenoviral serotypes classified within the subgroups B through F and demonstrate an enhanced therapeutic index.
La prEsente invention concerne des adEnovirus oncolytiques ayant des applications thErapeutiques. Sont fournis des adEnovirus chimères recombinEs et leurs mEthodes de production. Les adEnovirus chimères de l'invention comprennent des sEquences d'acide nuclEique dErivEes de sErotypes adEnoviraux classEs dans les sous-groupes B A F et font preuve d'un indice thErapeutique amEliorE.
Harden Paul
Hermiston Terry
Kuhn Irene
Marks & Clerk
Psioxus Therapeutics Limited
Schering Aktiengesellschaft
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