C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 39/12 (2006.01) C07K 14/18 (2006.01) C07K 19/00 (2006.01) C12N 15/40 (2006.01) C12N 15/79 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2448066
Chimeric alphaviruses and alphavirus replicon particles are provided including methods of making and using same. Specifically, alphavirus particles are provided having nucleic acid molecules derived from one or more alphaviruses and structural proteins (capsid and/or envelope) from at least two or more alphaviruses. Methods of making, using, and therapeutic preparations containing the chimeric alphavirus particle, are disclosed.
La présente invention concerne des alphavirus chimériques et des particules de réplicon d'alphavirus ainsi que des techniques de fabrication et d'utilisation de ceux-ci. Plus particulièrement, ces particules d'alphavirus possèdent des molécules d'acide nucléique dérivées d'un ou de plusieurs alphavirus et des protéines structurelles ( capside et/ou enveloppe) provenant d'au moins deux alphavirus. Cette invention concerne aussi des techniques de fabrication, d'utilisation et des préparations thérapeutiques contenant cette particule d'alphavirus chimérique.
Perri Silvia
Polo John
Thudium Kent
Borden Ladner Gervais Llp
Chiron Corporation
Novartis Vaccines And Diagnostics Inc.
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