C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 39/395 (2006.01) C07K 1/22 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2507099
The present invention provides chimeric and humanized antibodies that specifically recognize .alpha.5.beta.1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.
L'invention concerne des anticorps chimériques et humanisés, reconnaissant spécifiquement l'intégrine .alpha.5.beta.1, ainsi que des procédés d'utilisation des anticorps en vue de réduire ou d'inhiber l'angiogenèse dans un tissu. L'invention concerne en outre des procédés de détermination de doses thérapeutiquement acceptables des anticorps et de compositions pharmaceutiques renfermant ceux-ci.
Jeffry Ursula
Johnson Dale E.
Powers David
Ramakrishnan Vanitha
Abbott Biotherapeutics Corp.
Gowling Lafleur Henderson Llp
Protein Design Labs Inc.
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