C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/40 (2006.01) A61K 39/12 (2006.01) A61K 39/295 (2006.01) A61P 31/14 (2006.01) C07H 21/02 (2006.01) C07K 14/18 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2116980
The invention includes a chimeric virus for use in a vaccine preparation having a genome comprising nucleic acid sequenees encoding at least one structural protein from one flavivirus and nucleic acid sequences encoding nonstructural protein, from another flavivirus. The genome preferably includes mutations within the viral. genome that reduce virus virulence and in a particularly preferred embodiment these vaccines are directed to flaviviruses such as dengue virus, tick-borne encephalitis virus and Japanese encephalitis virus.
Bray Michael
Chanock Robert
Lai Ching-Juh
Men Ruhe
Pletnev Alexander G.
Departmen T. Of Health And Human Services The United States Of America As Represented By The Secretary
Department Of Health And Human Services The Government Of The United States Of America As Represented By
Gowling Lafleur Henderson Llp
LandOfFree
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