Chimeric antibodies and their use

Details Chimeric antibodies and their use Chimeric antibodies and their use

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 47/48 (2006.01) C07K 16/46 (2006.01) C12N 5/18 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2057951

Abstract of the Disclosure Disclosed are monoclonal chimeric antibodies containing an anti-human fibrin antibody light chain variable region and/or anti-urokinase antibody light chain variable region in combination with an anti-human antibody light chain constant region. Further disclosed are DNAs comprising a DNA coding for said antibody and eukaryotic cells allowing expression of said antibodies. Said chimeric antibodies can be used for producing a thrombolytic protein complex, which is useful as thrombolytic agent, by immunologically binding a urokinase to the urokinase recognition site of said bispecific antibodies.

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