Chimeric antibodies directed against a human glycoprotein...

Details Chimeric antibodies directed against a human glycoprotein... Chimeric antibodies directed against a human glycoprotein...

C - Chemistry, Metallurgy

12

N

530/13, 195/1.11

C12N 15/13 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2022273

X-7581 Abstract The present invention discloses novel chimeric monoclonal antibodies, directed against proteoglycans of human melanoma cells, having antigen-specific variable regions of defined amino acid sequences. DNA constructs for the light and heavy chain variable regions comprising the novel antibodies of the invention are provided. Eukaryotic host cells capable of expression of the chimeric antibodies and comprising the novel chimeric antibody-encoding DNA constructs are also provided.

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