C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C07K 14/55 (2006.01) C07K 14/62 (2006.01) C07K 14/65 (2006.01) C07K 14/705 (2006.01) C07K 14/73 (2006.01) C07K 14/79 (2006.01) C07K 16/30 (2006.01) C07K 16/44 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01) C12N 15/16 (2006.01) C12N 15/19 (2006.01) G01N 33/567 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2078689
The present invention provides a modified chimeric monoclonal antibody comprising wo molecules of each of two differ- ent polypeptides. The shorter polypeptides function as the light chains of the antibody and the longer polypeptides function as the heavy chains of the antibody. Moreover; the polypeptide which functions as a heavy chain has a variable region characteristic of a first mammal and a constant region characteristic of a second mammal. Each polypeptide which functions as a light chain has a variable region characteristic of a mammal and a constant region characteristic of a mammal; wherein a receptor-binding ligand replaces at least a portion of the constant region of each of the polypeptides which function as the heavy chains of the an- tibody. Additionally, the present invention provides an immunologically reactive complex and a chimeric polypeptide. Finally, methods of using and producing the modified chimeric monoclonal antibodies; immuraologically reactive complexes, and chimer- ic polypeptides are provided herein.
Morrison Sherie L.
Shin Seung-Uon
Gowling Lafleur Henderson Llp
The Trustees Of Columbia University
The Trustees Of Columbia University In The City Of New York
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