Chimeric antibody fusion proteins for the recruitment and...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07H 21/04 (2006.01) C07K 14/52 (2006.01) C07K 14/54 (2006.01) C07K 14/55 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/32 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01) C12N 15/19 (2006.01) C12N 15/24 (2006.01) C12N 15/26 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2279547

The present invention relates to chimeric molecules for the stimulation of an antitumor immune response to facilitate immune eradication of breast, ovarian and other cancer cells. The chimeric molecules include a binding region which specifically binds to a tumor specific antigen and a chemokine and/or costimulatory ligand. The invention further provides methods for inducing a tumor specific immune response and compositions which can be administered to mammals.

Cette invention concerne l'utilisation de molécules chimeriques pour stimuler une réponse immunitaire antitumorale afin de faciliter l'éradication par le système immunitaire des cellules cancéreuses impliquées dans les cancers du sein et des ovaires et dans une région de liaison qui se lie spécifiquement à un antigène spécifique à une tumeur et une chémokine et/ou un ligand costimulant. Cette invention concerne également des procédés permettant d'induire une réponse immunitaire spécifique à la tumeur et des compositions pouvant être administrées à des mammifères.

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