C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 39/29 (2006.01) A61K 47/48 (2006.01) A61P 31/12 (2006.01) A61P 31/20 (2006.01) C07K 16/28 (2006.01) C12N 15/02 (2006.01) C12N 15/10 (2006.01) C12N 15/13 (2006.01) C12N 15/36 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2534911
Disclosed herein are compositions and methods for eliciting immune responses against antigens. In particular, the compounds and methods elicit immune responses against foreign antigens that are otherwise recognized by the host as "self~ antigens, thus breaking host tolerance to those antigens. Presenting the host immune system with a chimeric antigen comprising an immune response domain and a target binding domain, wherein the target binding domain comprises an antibody fragment, enhances the immune response against the foreign or tolerated antigen. Antigen presenting cells take up, process, and present the chimeric antigen, eliciting both a humoral and cellular immune response against the desired antigen.
Compositions et méthodes permettant de susciter des réponses immunitaires contre des antigènes. En particulier, lesdits composés et méthodes suscitent une réponse immunitaire contre des antigènes étrangers qui seraient sinon reconnus par l'hôte comme antigènes autologues, supprimant ainsi la tolérance de l'hôte vis-à-vis de ces antigènes. La présentation au système immunitaire hôte d'un antigène chimère comportant un domaine de réponse immunitaire et un domaine de liaison cible, le domaine de liaison cible comportant un fragment d'anticorps, favorise la réponse immunitaire contre l'antigène étranger ou toléré. Des cellules de présentation de l'antigène absorbent, traitent et présentent l'antigène chimère, suscitant une réponse immunitaire tant humorale que cellulaire contre l'antigène désiré.
George Rajan
Ma Allan
Noujaim Antoine
Tyrrell Lorne
Wang Dakun
Parlee Mclaws Llp
Virexx Medical Corp.
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