Chimeric antiidiotypic monoclonal antibodies

Details Chimeric antiidiotypic monoclonal antibodies Chimeric antiidiotypic monoclonal antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/42 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01) C12P 21/08 (2006.01) G01N 33/564 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2060626

4-18522/A Novel chimeric antiidiotypic monoclonal antibodies Abstract The invention concerns chimeric antiidiotypic monoclonal antibodies consisting of human constant regions and murine variable regions of an antibody which recognizes antibodies directed against HLA class II antigens, and derivatives thereof which retain the specificity of the chimeric antibody from which they are derived. These chimeric antiidiotypic monoclonal antibodies and derivatives have immune-regulatory functions and can therefore be used for diagnostic and therapeutic purposes, such as the treatment of autoimmune diseases.

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