Chimeric antiviral agents which incorporate rev binding...

Details Chimeric antiviral agents which incorporate rev binding... Chimeric antiviral agents which incorporate rev binding...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) C07H 21/02 (2006.01) C12N 9/22 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2229749

Methods and compositions for the treatment and diagnosis of viral infections are provided. These methods and compositions utilize the ability of Rev binding nucleic acids such as the SL II sequence from the HIV-1 Rev Response Element (RRE) to target therapeutic agents to the same sub-cellular location as viruses which contain RRE sequences. The use of the compositions of the invention as components of diagnostic assays, as prophylactic reagents, and in gene therapy vectors is also described.

On décrit des procédés et compositions de traitement et de diagnostic d'infections virales, qui tirent parti de la capacité qu'ont des acides nucléiques se liant à Rev, tels que la séquence SL II provenant de l'élément de réponse Rev (RRE) de VIH-1, à cibler des agents thérapeutiques au même emplacement subcellulaire que des virus qui contiennent des séquences RRE. On décrit ainsi l'utilisation de telles compositions, comme substances de dosages diagnostiques ou réactifs prophylactiques et dans des vecteurs de thérapie génique.

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