Chimeric biotin-binding papillomavirus protein

Details Chimeric biotin-binding papillomavirus protein Chimeric biotin-binding papillomavirus protein

C - Chemistry, Metallurgy

07

K

C07K 14/025 (2006.01) A61K 39/12 (2006.01) C07K 19/00 (2006.01) C12N 7/01 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2351614

The present invention provides a chimeric protein including a first domain which includes at least a portion of a papillomavirus L1 or L2 protein and a second domain which includes a biotin-binding polypeptide. The invention also provides papillomaviruses, capsomeres, and VLPs including such chimeric proteins and a method for delivering biotinylated substances to cells using such reagents.

L'invention concerne une protéine chimère comportant un premier domaine qui renferme au moins un fragment de protéine L1 ou L2 de papillomavirus, et un second domaine qui renferme un polypeptide se liant avec la biotine. L'invention concerne également des papillomavirus, des capsomères et des particules de type virus renfermant les protéines chimères considérées. L'invention concerne en outre un procédé qui permet de fournir des substances biotinylées aux cellules en utilisant comme réactifs les produits considérés.

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