Chimeric chains for receptor-associated signal transduction...

Details Chimeric chains for receptor-associated signal transduction... Chimeric chains for receptor-associated signal transduction...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/705 (2006.01) C07K 14/725 (2006.01) C07K 14/73 (2006.01) C07K 14/735 (2006.01) C07K 16/00 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2074825

Chimeric proteins and DNA sequences encoding chimeric proteins are provided where the chimeric proteins are characterized by an extracellular domain capable of binding to a ligand, a transmembrane domain and a cytoplasmic domain capable of activating a signaling pathway, The extracellular domain and cytoplasmic domain are not naturally found together. Binding of ligand to the extracellular domain results in transduction of a signal and activation of a signaling pathway in the cell, whereby the cell may be induced to carry out various functions relating to the signaling pathway. A wide variety of extracellular domains may be employed as receptors, where such domains may be naturally occuring or synthetic.

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