Chimeric cytokine receptors in lymphocytes

Details Chimeric cytokine receptors in lymphocytes Chimeric cytokine receptors in lymphocytes

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/18 (2006.01) C12N 15/19 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2160011

Recombinant polynucleotides are provided that encode chimeric cytokine receptors. The chimeric receptor is comprised of an extracellular domain derived from cytokine receptor A-R that binds cytokine A, fused to a transmembrane and cytoplasmic domain derived from cytokine receptor B-R that binds cytokine B. The figure depicts a chimeric receptor with a GM:GSF receptor extracellular domain fused to an IL 2 receptor transmembrane and cytoplasmic domain. When the chimeric receptor is expressed in a lymphocyte it lessens the growth dependency of the lymphocyte on cytokine B in the presence of cytokine A.

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