Chimeric cytokines and uses thereof

Details Chimeric cytokines and uses thereof Chimeric cytokines and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/19 (2006.01) A61K 47/48 (2006.01) C07K 14/52 (2006.01) C07K 14/765 (2006.01)

Patent

CA 2205572

Disclosed are chimeric proteins having a cytokine fused to an enzymatically inactive polypeptide which increases the circulating half-life of the cytokine. The chimeric proteins are useful for treating, inhibiting, or preventing a variety of conditions, including septic shock, granulomatous disorders, Type I diabetes, and various cancers (e.g., multiple myeloma) in a patient.

Protéines chimériques dans lesquelles une cytokine est liée à un polypeptide inactif sur le plan enzymatique qui accroît la période de circulation de la cytokine. Les protéines chimériques servent au traitement, à l'inhibition et à la prévention de diverses affections, y compris le choc septique, les désordres granulomateux, le diabète insulinodépendant et divers cancers (comme le myélome multiple).

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