Chimeric cytoplasmic signalling molecules

Details Chimeric cytoplasmic signalling molecules Chimeric cytoplasmic signalling molecules

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2503888

Nucleic acids are described which code for chimeric cytoplasmic signalling molecules containing at least one cytoplasmic signalling sequence derived from CD134 or ICOS. The nucleic acids may be expressed in cells to produce chimeric receptors and other proteins which are able to regulate cell activation processes. Such regulated cells are of use in medicine, for example in the treatment of infectious, inflammatory and autoimmune diseases.

L'invention concerne des acides nucléiques qui codent les molécules de signalisation cytoplasmiques chimères contenant au moins une séquence de signalisation cytoplasmique dérivée de CD134 ou ICOS. Lesdits acides nucléiques sont utilisés en médecine, par exemple dans le traitement de maladies infectieuses, inflammatoires et auto-immunes.

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