Chimeric dna-rna catalytic sequences

Details Chimeric dna-rna catalytic sequences Chimeric dna-rna catalytic sequences

C - Chemistry, Metallurgy

07

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C07H 21/04 (2006.01) B64D 13/06 (2006.01) C12N 15/11 (2006.01) F25B 9/00 (2006.01) F25B 11/04 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2039718

This invention provides chimeric DNA/RNA catalytic molecules useful to cleave RNA sequences. The invention specif- cally provides two different chimeric DNA-RNA-DNA-RNA-DNA catalytic molecules which are targeted to cleave HIV-1 RNA sequences. These chimeric molecules include DNA sequences which flank a catalytic RNA enter. Interaction with the HIV-1 substrate RNAs is achieved by Watson-Crick base pairing of the DNA flanking sequences with HIV-I RNA. The catalytic ribonucleotide center cleaves the phosphodiester bond of the substrate HIV-I RNA at the expected location.

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