Chimeric empty capsids of the infectious bursal disease...

C - Chemistry – Metallurgy – 12 – N

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C12N 7/04 (2006.01) A61K 39/12 (2006.01) C07K 14/08 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/86 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2553756

The chimeric empty capsids of the infectious bursal disease virus (IBDV), are constituted by assembly of (i) IBDV pVP2 proteins and (ii) fusion proteins comprising a region A constituted by the IBDV VP3 protein bound to a region B constituted by a heterologous polypeptide comprising a polypeptide of interest, such as a polypeptide useful in vaccination, therapy or diagnosis.

Des capsides vides chimères du virus de la bursite infectieuse (VBI) sont constitués par l'assemblage de protéines (i) IBDV pVP2 et de protéines de fusion (ii) comprenant une région A constituée de la protéine IBDV VP3 liée à une région B constituée d'un polypeptide hétérologue comprenant un polypeptide d'intérêt, notamment un polypeptide utile dans les vaccins, les thérapies ou les diagnostics.

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