C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/04 (2006.01) A61K 39/12 (2006.01) C12N 7/02 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2615468
The chimeric empty viral-like particles derived from the infectious bursal disease virus (IBDV) are formed by the assembly of fusion proteins comprising a region A comprising an IBDV pVP2 protein or a "1-n" fragment of said IBDV pVP2, wherein "n" is an integer comprised between 441 and 501, and a region B comprising a heterologous polypeptide comprising a polypeptide of interest, such as a polypeptide useful for prophylactic, therapeutic or diagnostic purposes.
La présente invention concerne des particules chimériques vides d'apparence virale tirées du virus de la bursite infectieuse (IBDV). Ces particules sont un assemblage de protéines de fusion comprenant une région A et une région B. La région A comporte une protéine pVP2 de l'IBDV, ou l'un de ses fragments "1-n" tel que 441<=n<=501. La région B est pourvue d'un polypeptide hétérologue, avec notamment un polypeptide intéressant pour ses fonctions prophylactiques, thérapeutiques ou de diagnostic.
Ona Blanco Ana Maria
Rodriguez Aguirre Jose Francisco
Rodriguez Fernandez-Alba Juan Ramon
Ruiz Caston Jose
Saugar Gomez Irene
Bionostra S.l.
Consejo Superior de Investigaciones Cientificas
Gowling Lafleur Henderson Llp
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