Chimeric fibroblast growth factor

Details Chimeric fibroblast growth factor Chimeric fibroblast growth factor

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) C07K 14/50 (2006.01)

Patent

CA 2055963

The present invention relates to novel chimeric fibroblast growth factors (FGF) wherein the alanine at amino acid 3 and serine 5 of native human recombinant basic fibroblast growth factor are replaced with glutamic acid. The N-terminus sequence of the present chimeric FGFs identify homology with that of human acidic fibroblast growth factor. The mitogenic properties of the native human recombinant basic FGF are exhibited by the present chimeric FGFs, and they are efficiently expressed in E. coli at significantly greater yields that previously reported. Novel variants of this new glu3,5 basic fibroblast growth factor, such as those in which cysteine 78 and cysteine 96 are replaced, e.g., with serine or other amino acids, to produce stabilized versions of the glu3,5 basic FGF and eliminate disulfide scrambled forms, are also described.

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