Chimeric flavivirus vaccines

Details Chimeric flavivirus vaccines Chimeric flavivirus vaccines

A - Human Necessities

61

K

A61K 39/12 (2006.01) A61K 39/193 (2006.01) C07K 14/18 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2282790

A chimeric live, infectious, attenuated virus, containing a yellow fever virus, in which the nucleotide sequence for a prM-E protein is either deleted, truncated, or mutated, so that functional prM-E protein is not expressed, and integrated into the genome of the yellow fever virus, a nucleotide sequence encoding a prM-E protein of a second, different flavivirus, so that the prM-E protein of the second flavivirus is expressed.

Cette invention se rapporte à un vaccin chimère vivant, infectieux, atténué, qui contient un virus de fièvre jaune, dans lequel la séquence nucléotidique associée à une protéine prM-E est soit supprimée, tronquée ou soumise à une mutation, de sorte que la protéine fonctionnelle prM-E n'est pas exprimée, puis intégrée au génome du virus de la fièvre jaune, une séquence nucléotidique codant une protéine prM-E d'un second virus différent de sorte que la protéine prM-E du second flavivirus est exprimée.

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