Chimeric glycosylphosphatidylinositol containing peptides

Details Chimeric glycosylphosphatidylinositol containing peptides Chimeric glycosylphosphatidylinositol containing peptides

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) C07K 14/715 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/19 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2494706

The present invention relates to polypeptides which comprise a receptor binding domain of a cytokine and a domain which includes a signal sequence for the attachment of glycosylphosphatidylinositol (GPI) anchors. The invention also relates to methods to manufacture the polypeptides, nucleic acids molecules encoding the polypeptides and therapeutic compositions comprising the polypeptides.

Cette invention se rapporte à des polypeptides qui comprennent un domaine d'une cytokine se fixant aux récepteurs et un domaine qui contient une séquence signal pour la fixation des ancres au glycosylphosphatidylinositol (GPI). Cette invention concerne également des procédés pour la fabrication de ces polypeptides, des molécules d'acides nucléiques codant ces polypeptides et des compostions thérapeutiques comprenant ces polypeptides.

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