C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A61K 35/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12P 21/02 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2621973
This invention provides a chimeric hyperpolarization-activated, cyclic nucleotide-gated (HCN) polypeptide comprising portions of more than one type of HCN channel. The invention also provides methods of treating a subject afflicted with a cardiac rhythm disorder comprising expression of the chimeric HCN polypeptide in a selected region of the heart so as to induce a pacemaker current in the heart and thereby treat the subject.
L'invention concerne un polypeptide chimère activé par hyperpolarisation et sensible aux nucléotides cycliques (HCN), qui comprend des parties de plus d'un type de canal HCN. L'invention concerne aussi des méthodes de traitement d'un sujet présentant un trouble du rythme cardiaque, qui comprennent l'étape consistant à exprimer le polypeptide chimère HCN dans une région sélectionnée du coeur afin d'induire un courant de stimulateur cardiaque dans le coeur, de manière à traiter le sujet.
Brink Peter R.
Cohen Ira S.
Robinson Richard B.
Rosen Michael R.
Gowling Lafleur Henderson Llp
The Research Foundation Of The State University Of New York
The Trustees Of Columbia University In The City Of New York
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